Concern about the ethics of clinical drug trials research on patients and healthy volunteers has been the subject of significant ethical analysis and policy development—protocols are reviewed by Research Ethics Committees and subjects are protected by informed consent procedures. More recently attention has begun to be focused on DNA banking for clinical and pharmacogenetics research. It is, however, surprising how little attention has been paid to the commercial nature of such research, or the unique issues that present when subjects are (...) asked to consent to the storage of biological samples. Our contention is that in the context of pharmacogenetic add-on studies to clinical drug trials, the doctrine of informed consent fails to cover the broader range of social and ethical issues. Applying a sociological perspective, we foreground issues of patient/subject participation or ‘work’, the ambiguity of research subject altruism, and the divided loyalties facing many physicians conducting clinical research. By demonstrating the complexity of patient and physician involvement in clinical drug trials, we argue for more comprehensive ethical review and oversight that moves beyond reliance on informed consent to incorporate understandings of the social, political and cultural elements that underpin the diversity of ethical issues arising in the research context. (shrink)

Concern about the ethics of clinical drug trials research on patients and healthy volunteers has been the subject of significant ethical analysis and policy development—protocols are reviewed by Research Ethics Committees and subjects are protected by informed consent procedures. More recently attention has begun to be focused on DNA banking for clinical and pharmacogenetics research. It is, however, surprising how little attention has been paid to the commercial nature of such research, or the unique issues that present when subjects are (...) asked to consent to the storage of biological samples. Our contention is that in the context of pharmacogenetic add-on studies to clinical drug trials, the doctrine of informed consent fails to cover the broader range of social and ethical issues. Applying a sociological perspective, we foreground issues of patient/subject participation or ‘work’, the ambiguity of research subject altruism, and the divided loyalties facing many physicians conducting clinical research. By demonstrating the complexity of patient and physician involvement in clinical drug trials, we argue for more comprehensive ethical review and oversight that moves beyond reliance on informed consent to incorporate understandings of the social, political and cultural elements that underpin the diversity of ethical issues arising in the research context. (shrink)

To make sense of what Gilles Deleuze understands by a mathematical concept requires unpacking what he considers to be the conceptualizable character of a mathematical theory. For Deleuze, the mathematical problems to which theories are solutions retain their relevance to the theories not only as the conditions that govern their development, but also insofar as they can contribute to determining the conceptualizable character of those theories. Deleuze presents two examples of mathematical problems that operate in this way, which he considers (...) to be characteristic of a more general theory of mathematical problems. By providing an account of the historical development of this more general theory, which he traces drawing upon the work of Weierstrass, Poincaré, Riemann, and Weyl, and of its significance to the work of Deleuze, an account of what a mathematical concept is for Deleuze will be developed. (shrink)

In the paper “Math Anxiety,” Aden Evens explores the manner by means of which concepts are implicated in the problematic Idea according to the philosophy of Gilles Deleuze. The example that Evens draws from Difference and Repetition in order to demonstrate this relation is a mathematics problem, the elements of which are the differentials of the differential calculus. What I would like to offer in the present paper is an historical account of the mathematical problematic that Deleuze deploys in his (...) philosophy, and an introduction to the role that this problematic plays in the develop- ment of his philosophy of difference. One of the points of departure that I will take from the Evens paper is the theme of “power series.”2 This will involve a detailed elaboration of the mechanism by means of which power series operate in the differential calculus deployed by Deleuze in Difference and Repetition. Deleuze actually constructs an alternative history of mathematics that establishes an historical conti- nuity between the differential point of view of the infinitesimal calculus and modern theories of the differential calculus. It is in relation to the differential point of view of the infinitesimal calculus that Deleuze determines a differential logic which he deploys, in the form of a logic of different/ciation, in the development of his proj- ect of constructing a philosophy of difference. (shrink)

Maimon’s theory of the differential has proved to be a rather enigmatic aspect of his philosophy. By drawing upon mathematical developments that had occurred earlier in the century and that, by virtue of the arguments presented in the Essay and comments elsewhere in his writing, I suggest Maimon would have been aware of, what I propose to offer in this paper is a study of the differential and the role that it plays in the Essay on Transcendental Philosophy (1790). In (...) order to do so, this paper focuses upon Maimon’s criticism of the role played by mathematics in Kant’s philosophy, to which Maimon offers a Leibnizian solution based on the infinitesimal calculus. The main difficulties that Maimon has with Kant’s system, the second of which will be the focus of this paper, include the presumption of the existence of synthetic a priori judgments, i.e. the question quid facti, and the question of whether the fact of our use of a priori concepts in experience is justified, i.e. the question quid juris. Maimon deploys mathematics, specifically arithmetic, against Kant to show how it is possible to understand objects as having been constituted by the very relations between them, and he proposes an alternative solution to the question quid juris, which relies on the concept of the differential. However, despite these arguments, Maimon remains sceptical with respect to the question quid facti. (shrink)

According to the reading of Spinoza that Gilles Deleuze presents in Expressionism in Philosophy: Spinoza, Spinoza's philosophy should not be represented as a moment that can be simply subsumed and sublated within the dialectical progression of the history of philosophy, as it is figured by Hegel in the Science of Logic, but rather should be considered as providing an alternative point of view for the development of a philosophy that overcomes Hegelian idealism. Indeed, Deleuze demonstrates, by means of Spinoza, that (...) a more complex philosophy antedates Hegel's which cannot be supplanted by it. Spinoza therefore becomes a significant figure in Deleuze's project of tracing an alternative lineage in the history of philosophy, which, by distancing itself from Hegelian idealism, culminates in the construction of a philosophy of difference. Deleuze presents Spinoza's metaphysics as determined according to a 'logic of expression', which, insofar as it contributes to the determination of a philosophy of difference, functions as an alternative to the Hegelian dialectical logic. Deleuze's project in Expressionism in Philosophy is therefore to redeploy Spinoza in order to mobilize his philosophy of difference as an alternative to the dialectical philosophy determined by the Hegelian dialectic logic. (shrink)

Of all twentieth century philosophers, it is Gilles Deleuze whose work agitates most forcefully for a worldview privileging becoming over being, difference over sameness; the world as a complex, open set of multiplicities. Nevertheless, Deleuze remains singular in enlisting mathematical resources to underpin and inform such a position, refusing the hackneyed opposition between ‘static’ mathematical logic versus ‘dynamic’ physical world. This is an international collection of work commissioned from foremost philosophers, mathematicians and philosophers of science, to address the wide range (...) of problematics and influences in this most important strand of Deleuze’s thinking. Contributors are Charles Alunni, Alain Badiou, Gilles Châtelet, Manuel DeLanda, Simon Duffy, Robin Durie, Aden Evens, Arkady Plotnitsky, Jean-Michel Salanskis, Daniel Smith and David Webb. (shrink)

What I plan to do in this paper is to provide a survey of the ways in which Spinoza’s philosophy has been deployed in relation to early modern thought, in the history of ideas and in a number of different domains of contemporary philosophy, and to offer an account of how some of this research has developed. The past decade of research in Spinoza studies has been characterized by a number of tendencies; however, it is possible to identify four main (...) domains that characterize these different lines of research: studies of Spinoza’s individual works, of its problematic concepts, from the point of view of the history of ideas, and comparative studies of Spinoza’s ideas. (shrink)

The reconstruction of Leibniz’s metaphysics that Deleuze undertakes in The Fold provides a systematic account of the structure of Leibniz’s metaphysics in terms of its mathematical foundations. However, in doing so, Deleuze draws not only upon the mathematics developed by Leibniz—including the law of continuity as reflected in the calculus of infinite series and the infinitesimal calculus—but also upon developments in mathematics made by a number of Leibniz’s contemporaries—including Newton’s method of fluxions. He also draws upon a number of subsequent (...) developments in mathematics, the rudiments of which can be more or less located in Leibniz’s own work—including the theory of functions and singularities, the Weierstrassian theory of analytic continuity, and Poincaré’s theory of automorphic functions. Deleuze then retrospectively maps these developments back onto the structure of Leibniz’s metaphysics. While the Weierstrassian theory of analytic continuity serves to clarify Leibniz’s work, Poincaré’s theory of automorphic functions offers a solution to overcome and extend the limits that Deleuze identifies in Leibniz’s metaphysics. Deleuze brings this elaborate conjunction of material together in order to set up a mathematical idealization of the system that he considers to be implicit in Leibniz’s work. The result is a thoroughly mathematical explication of the structure of Leibniz’s metaphysics. This essay is an exposition of the very mathematical underpinnings of this Deleuzian account of the structure of Leibniz’s metaphysics, which, I maintain, subtends the entire text of The Fold. (shrink)

Explications of the reconstruction of Leibniz’s metaphysics that Deleuze undertakes in 'The Fold: Leibniz and the Baroque' focus predominantly on the role of the infinitesimal calculus developed by Leibniz.1 While not underestimat- ing the importance of the infinitesimal calculus and the law of continuity as reflected in the calculus of infinite series to any understanding of Leibniz’s metaphysics and to Deleuze’s reconstruction of it in The Fold, what I propose to examine in this paper is the role played by other (...) developments in mathematics that Deleuze draws upon, including those made by a number of Leibniz’s near contemporaries – the projective geometry that has its roots in the work of Desargues (1591–1661) and the ‘proto-topology’ that appears in the work of Du ̈rer (1471–1528) – and a number of the subsequent developments in these fields of mathematics. Deleuze brings this elaborate conjunction of material together in order to set up a mathematical idealization of the system that he considers to be implicit in Leibniz’s work. The result is a thoroughly mathematical explication of the structure of Leibniz’s metaphysics. What is provided in this paper is an exposition of the very mathematical underpinnings of this Deleuzian account of the structure of Leibniz’s metaphysics, which, I maintain, subtends the entire text of The Fold. (shrink)

In the chapter of Difference and Repetition entitled ‘Ideas and the synthesis of difference,’ Deleuze mobilizes mathematics to develop a ‘calculus of problems’ that is based on the mathematical philosophy of Albert Lautman. Deleuze explicates this process by referring to the operation of certain conceptual couples in the field of contemporary mathematics: most notably the continuous and the discontinuous, the infinite and the finite, and the global and the local. The two mathematical theories that Deleuze draws upon for this purpose (...) are the differential calculus and the theory of dynamical systems, and Galois’ theory of polynomial equations. For the purposes of this paper I will only treat the first of these, which is based on the idea that the singularities of vector fields determine the local trajectories of solution curves, or their ‘topological behaviour’. These singularities can be described in terms of the given mathematical problematic, that is for example, how to solve two divergent series in the same field, and in terms of the solutions, as the trajectories of the solution curves to the problem. What actually counts as a solution to a problem is determined by the specific characteristics of the problem itself, typically by the singularities of this problem and the way in which they are distributed in a system. Deleuze understands the differential calculus essentially as a ‘calculus of problems’, and the theory of dynamical systems as the qualitative and topological theory of problems, which, when connected together, are determinative of the complex logic of different/ciation. (DR 209). Deleuze develops the concept of a problematic idea from the differential calculus, and following Lautman considers the concept of genesis in mathematics to ‘play the role of model ... with respect to all other domains of incarnation’. While Lautman explicated the philosophical logic of the actualization of ideas within the framework of mathematics, Deleuze (along with Guattari) follows Lautman’s suggestion and explicates the operation of this logic within the framework of a multiplicity of domains, including for example philosophy, science and art in What is Philosophy?, and the variety of domains which characterise the plateaus in A Thousand Plateaus. While for Lautman, a mathematical problem is resolved by the development of a new mathematical theory, for Deleuze, it is the construction of a concept that offers a solution to a philosophical problem; even if this newly constructed concept is characteristic of, or modelled on the new mathematical theory. (shrink)

In Hegel ou Spinoza,1 Pierre Macherey challenges the influence of Hegel’s reading of Spinoza by stressing the degree to which Spinoza eludes the grasp of the Hegelian dialectical progression of the history of philosophy. He argues that Hegel provides a defensive misreading of Spinoza, and that he had to “misread him” in order to maintain his subjective idealism. The suggestion being that Spinoza’s philosophy represents, not a moment that can simply be sublated and subsumed within the dialectical progression of the (...) history of philosophy, but rather an alternative point of view for the development of a philosophy that overcomes Hegelian idealism. Gilles Deleuze also considers Spinoza’s philosophy to resist the totalising effects of the dialectic. Indeed, Deleuze demonstrates, by means of Spinoza, that a more complex philosophy antedates Hegel’s, which cannot be supplanted by it. Spinoza therefore becomes a significant figure in Deleuze’s project of tracing an alternative lineage in the history of philosophy, which, by distancing itself from Hegelian idealism, culminates in the construction of a philosophy of difference. It is Spinoza’s role in this project that will be demonstrated in this paper by differentiating Deleuze’s interpretation of the geometrical example of Spinoza’s Letter XII (on the problem of the infinite) in Expressionism in Philosophy, Spinoza,2 from that which Hegel presents in the Science of Logic.3. (shrink)

Plato’s philosophy is important to Badiou for a number of reasons, chief among which is that Badiou considered Plato to have recognised that mathematics provides the only sound or adequate basis for ontology. The mathematical basis of ontology is central to Badiou’s philosophy, and his engagement with Plato is instrumental in determining how he positions his philosophy in relation to those approaches to the philosophy of mathematics that endorse an orthodox Platonic realism, i.e. the independent existence of a realm of (...) mathematical objects. The Platonism that Badiou makes claim to bears little resemblance to this orthodoxy. Like Plato, Badiou insists on the primacy of the eternal and immu- table abstraction of the mathematico-ontological Idea; however, Badiou’s reconstructed Platonism champions the mathematics of post-Cantorian set theory, which itself af rms the irreducible multiplicity of being. Badiou in this way recon gures the Platonic notion of the relation between the one and the multiple in terms of the multiple-without-one as represented in the axiom of the void or empty set. Rather than engage with the Plato that is gured in the ontological realism of the orthodox Platonic approach to the philosophy of mathematics, Badiou is intent on characterising the Plato that responds to the demands of a post-Cantorian set theory, and he considers Plato’s philosophy to provide a response to such a challenge. In effect, Badiou reorients mathematical Platonism from an epistemological to an ontological problematic, a move that relies on the plausibility of rejecting the empiricist ontology underlying orthodox mathematical Platonism. To draw a connec- tion between these two approaches to Platonism and to determine what sets them radically apart, this paper focuses on the use that they each make of model theory to further their respective arguments. (shrink)

The role of mathematics in the development of Gilles Deleuze's (1925-95) philosophy of difference as an alternative to the dialectical philosophy determined by the Hegelian dialectic logic is demonstrated in this paper by differentiating Deleuze's interpretation of the problem of the infinitesimal in Difference and Repetition from that which G. W. F Hegel (1770-1831) presents in the Science of Logic . Each deploys the operation of integration as conceived at different stages in the development of the infinitesimal calculus in his (...) treatment of the problem of the infinitesimal. Against the role that Hegel assigns to integration as the inverse transformation of differentiation in the development of his dialectical logic, Deleuze strategically redeploys Leibniz's account of integration as a method of summation in the form of a series in the development of his philosophy of difference. By demonstrating the relation between the differential point of view of the Leibnizian infinitesimal calculus and the differential calculus of contemporary mathematics, I argue that Deleuze effectively bypasses the methods of the differential calculus which Hegel uses to support the development of the dialectical logic, and by doing so, sets up the critical perspective from which to construct an alternative logic of relations characteristic of a philosophy of difference. The mode of operation of this logic is then demonstrated by drawing upon the mathematical philosophy of Albert Lautman (1908-44), which plays a significant role in Deleuze's project of constructing a philosophy of difference. Indeed, the logic of relations that Deleuze constructs is dialectical in the Lautmanian sense. (shrink)

The theme of the conflict between the different interpretations of Spinoza’s philosophy in French scholarship, introduced by Christopher Norris in this volume and expanded on by Alain Badiou, is also central to the argument presented in this chapter. Indeed, this chapter will be preoccupied with distinguishing the interpretations of Spinoza by two of the figures introduced by Badiou. The interpretation of Spinoza offered by Gilles Deleuze in Expressionism in Philosophy provides an account of the dynamic changes or transformations of the (...) characteristic relations of a Spinozist finite existing mode, or human being. This account has been criticized more or less explicitly by a number of commentators, including Charles Ramond. Rather than providing a defence of Deleuze on this specific point, which I have done elsewhere, what I propose to do in this chapter is provide an account of the role played by “joyful passive a affections” in these dynamic changes or transformations by distinguishing Deleuze’s account of this role from that offered by one of his more explicit critics on this issue, Pierre Macherey. An appreciation of the role played by “joyful passive affections” in this context is crucial to understanding how Deleuze’s interpretation of Spinoza is implicated in his broader philosophical project of constructing a philosophy of difference. The outcome is a position that, like Badiou in the previous chapter, rules out “intellect in potentiality” but maintains a role for the joyful passive affects in the development of adequate ideas. (shrink)

This thesis sets out an argument in defence of moral objectivism. It takes Mackie as the critic of objectivism and it ends by proposing that the best defence of objectivism may be found in what I shall call Kantian intuitionism, which brings together elements of the intuitionism of Ross and a Kantian epistemology. The argument is fundamentally transcendental in form and it proceeds by first setting out what we intuitively believe, rejecting the sceptical attacks on those beliefs, and by then (...) proposing a theory that can legitimize what we already do believe. Chapter One sets out our intuitive understanding of morality: that morality is cognitive, moral beliefs can be true or false; that morality is real, we do not construct it; that morality is rational, we can learn about it by rational investigation; and that morality places us under an absolute constraint. The chapter ends by clarifying the nature of that absolute demand and by arguing that the critical idea within morality is the idea of duty. In Chapter Two Mackie’s sceptical attack on objectivism is examined. Four key arguments are identified: that moral beliefs are relative to bfferent agents; that morality is based upon on non-rational causes; that the idea of moral properties or entities is too queer to be sustainable; and that moral objectivism involves queer epistemological commitments. Essentially all of these arguments are shown to be ambiguous; however it is proposed that Mackie has an underlying epistemological and metaphysical theory, scientific empiricism, which is hostile to objectivism and a theory that many find attractive for reasons that are independent of morality. Chapter Three explores the nature of moral rationality and whether scientific empiricism can use the idea of reflective equilibrium to offer a reasonable account of moral rationality. It concludes that, while reflective equilibrium is a useful account of moral rationality, it cannot be effectively reconciled with scientific empiricism. In order to function effectively as a rational process, reflective equilibrium must be rationally constrained by our moral judgements and our moral principles. Chapter Four begins the process of exploring some alternative epistemologies and argues that the only account that remains true to objectivism and the needs of reflective equilibrium is the account of intuitionism proposed by Ross. However this account can be developed further by drawing upon number of Kantian ideas and using them to supplement Ross’s intuitionism. So Chapter Five draws upon a number of Kant's ideas, most notably some key notions from the Critique of Judgement. These ideas are: that we possess a rational will that is subject to the Moral law and determined by practical reason; that we possess a faculty of judgement which enables us to become aware of moral properties and that these two faculties together with the third faculty of thought can function to constitute the moral understanding. Using these ideas the thesis explores whether they can serve to explain how intuitions can be rational and how objectivism can be justified. (shrink)

Within the cognitive science of religion, some scholars hypothesize (1) that minimally counterintuitive (MCI) concepts enjoy a transmission advantage over both intuitive and highly counterintuitive concepts, (2) that religions concern counterintuitive agents, objects, or events, and (3) that the transmission advantage of MCI concepts makes them more likely to be found in the world’s religions than other kinds of concepts. We hypothesized that the memorability of many MCI supernatural concepts was due in large part to other characteristics they possess, such (...) as their frequent and salient association with moral concerns and the alleviation of existential anxieties, and that without such characteristics they would fail to be memorable. We report the results of three experiments designed to test the relative contributions of minimal counterintuitiveness, moral valence, and existential anxiety to the memorability of supernatural ideas. We observed no main effects for minimal counterintuitiveness but did observe main effects for both moral valence and existential anxiety. We also found that these effects did not seem to stem from the greater visualizability of morally valenced concepts or concepts that concerned existential anxieties. These findings challenge important claims made by leading researchers regarding MCI concepts within the cognitive science of religion. (shrink)

This article examines the seventeenth-century debate between the Dutch philosopher Benedict de Spinoza and the British scientist Robert Boyle, with a view to explicating what the twentieth-century French philosopher Gilles Deleuze considers to be the difference between science and philosophy. The two main themes that are usually drawn from the correspondence of Boyle and Spinoza, and used to polarize the exchange, are the different views on scientific methodology and on the nature of matter that are attributed to each correspondent. Commentators (...) have tended to focus on one or the other of these themes in order to champion either Boyle or Spinoza in their assessment of the exchange. This paper draws upon the resources made available by Gilles Deleuze and Felix Guattari in their major work What is Philosophy?, in order to offer a more balanced account of the exchange, which in its turn contributes to our understanding of Deleuze and Guattari’s conception of the difference between science and philosophy. (shrink)

The aim of this chapter is to test the degree to which Deleuze’s philosophy can be reconciled with the subject naturalist approach to pragmatism put forward by Macarthur and Price.

Much has been made of Deleuze’s Neo-Leibnizianism,3 however not very much detailed work has been done on the specific nature of Deleuze’s critique of Leibniz that positions his work within the broader framework of Deleuze’s own philo- sophical project. The present chapter undertakes to redress this oversight by providing an account of the reconstruction of Leibniz’s metaphysics that Deleuze undertakes in The Fold. Deleuze provides a systematic account of the structure of Leibniz’s metaphys- ics in terms of its mathematical underpinnings. (...) However, in doing so, Deleuze draws upon not only the mathematics developed by Leibniz – including the law of continuity as reflected in the calculus of infinite series and the infinitesimal calculus – but also the developments in mathematics made by a number of Leibniz’s contemporaries – including Newton’s method of fluxions – and a number of subsequent developments in mathematics, the rudiments of which can be more or less located in Leibniz’s own work – including the theory of functions and singularities, the theory of continuity and Poincaré’s theory of automorphic functions. Deleuze then retrospectively maps these developments back onto the structure of Leibniz’s metaphysics. While the theory of continuity serves to clarify Leibniz’s work, Poincaré’s theory of automorphic functions offers a solution to overcome and extend the limits that Deleuze identifies in Leibniz’s metaphysics. Deleuze brings this elaborate conjunction of material together in order to set up a mathematical idealization of the system that he considers to be implicit in Leibniz’s work. The result is a thoroughly mathematical explication of the structure of Leibniz’s metaphysics. What is provided in this chapter is an exposition of the very mathematical underpinnings of this Deleuzian account of the structure of Leibniz’s metaphysics, which, I maintain, subtends the entire text of The Fold. (shrink)

Michiel Wielema: The March of the Libertines. Spinozists and the Dutch Reformed Church (1660–1750). ReLiC: Studies in Dutch Religious History. Hilversum: Uitgeverij Verloren, 2004; pp. 221. The Dutch Republic of the seventeenth century is famous for having cultivated an extraordinary climate of toleration and religious pluralism — the Union of Utrecht supported religious freedom, or “freedom of conscience”, and expressly forbade reli- gious inquisition. However, despite membership in the state sponsored Calvinist Dutch Reformed Church not being compulsory, the freedom to (...) gather and worship, or “to air anti-Christian or atheistic opinions” was little tolerated “within” the organized structure of the church, which functioned more as “an exclusive organisation for those willing to submit freely to certain confessional canons and to the disciplinary author- ity of the church’s governing bodies” (10): the consistories, classes, and synods. Those not prepared to submit to Reformed doctrine were free to leave the church without fear of any legal or political repercussions. However, for those not prepared to leave for reasons of personal belief, matters turned out to be quite different. Because the Reformed Church enjoyed full State protection, matters of doctrinal conflict could well evolve into political affairs. And, contrary to the Union of Utrecht, religious inquisition was in some cases actually applied with political approval for “heretics” within the Reformed Church. The main focus of The March of the Libertines is an investigation of this obvious tension. (shrink)

We provide an analysis of the public's having warranted epistemic trust in science, that is, the conditions under which the public may be said to have well-placed trust in the scientists as providers of information. We distinguish between basic and enhanced epistemic trust in science and provide necessary conditions for both. We then present the controversy regarding the connection between autism and measles–mumps–rubella vaccination as a case study to illustrate our analysis. The realization of warranted epistemic public trust in science (...) requires various societal conditions, which we briefly introduce in the concluding section. (shrink)

Augmented Reality (AR), driven by Artificial Intelligence (AI), is transforming how we interact with the world. Recent technologies, like AI-powered smart glasses, are increasingly blending the physical and digital realms. While AR presents exciting new possibilities, it also raises deeper philosophical questions about what we consider reality.

Through a Gadamerian critique of Enlightenment objectivism, the discussion of right and wrong perception is based on the minimums of immediate illegitimizing of certain prejudices and the determining of one’s own perception as right or wrong in opposition to expertise; this ultimately allows knowledge to be laid out in an anti-relativist position whilst still permitting diversity of perception, proving that opinion necessitates its own change and development over time on both the micro and macro levels of thought.

In this article, we develop a new approach to integrating philosophical phenomenology with qualitative research. The approach uses phenomenology’s concepts, namely existentials, rather than methods such as the epoché or reductions. We here introduce the approach to both philosophers and qualitative researchers, as we believe that these studies are best conducted through interdisciplinary collaboration. In section 1, we review the debate over phenomenology’s role in qualitative research and argue that qualitative theorists have not taken full advantage of what philosophical phenomenology (...) has to offer, thus motivating the need for new approaches. In section 2, we introduce our alternative approach, which we call Phenomenologically Grounded Qualitative Research (PGQR). Drawing parallels with phenomenology’s applications in the cognitive sciences, we explain how phenomenological grounding can be used to conceptually front-load a qualitative study, establishing an explicit focus on one or more structures of human existence, or of our being in the world. In section 3, we illustrate this approach with an example of a qualitative study carried out by one of the authors: a study of the existential impact of early parental bereavement. In section 4, we clarify the kind of knowledge that phenomenologically grounded studies generate and how it may be integrated with existing approaches. (shrink)

Güvenilirci (reliabilist) bilgi teorisi, çağdaş epistemik gerekçelendirme kuramları içerisinde, dışsalcı (externalist) kuramın bir türü olarak kendisine yer bulmaktadır. Kısaca, bir inancı gerekçelendiren şeyin o inancın oluşturulduğu sürecin güvenilirliği olduğunu öne süren bu yaklaşım, bu bilişsel süreçleri özne dışı unsurlara bağladığı içinde dışsalcı bir pozisyonda yer almaktadır. Bu bilgi teorisinin tam karşı konumunda yer alan içselci (internalist) bilgi teorisi ise, özne merkezli bir yaklaşımla, doğru inancı gerekçelendirecek yöntemin, kişinin kendi zihinsel yapısından yola çıkarak, belli kognitif süreçler sonucunda ulaşılabileceğini öne sürmektedir. Epistemik (...) gerekçelendirme kuramları içerisinde birçok tartışmada kendisine yer bulan bu iki bilgi teorisi, kendi içerisinde de birçok farklı kurama kapı aralamıştır. Burada içselci bilgi teorisinden ortaya çıkan erişim içselciliği, farkındalık içselciliği gibi kuramları ve dışsalcı bilgi teorisinden ortaya çıkan süreç güvenilirciliği, gösterge güvenilirciliği ve erdem güvenilirciliği gibi farklı türden kuramları örnek olarak verebiliriz. Öte yandan çağdaş epistemolojideki bu tartışmalar, dini epistemoloji içerisinde de kendisine yer bulmuştur. Özellikle Alvin Plantinga, kendi dini epistemolojisi içerisinde dışsalcı bir tutum sergilemiş ve son dönem çalışmaları içerisinde de güvenilirci bir anlayışla Tanrı inancının epistemik mahiyetini ortaya koymaya çalışmıştır. Bu makalede öncelikle dışsalclık ve onun bir türü olan güvenilirci bilgi anlayışını ve bu kuramlara getirilen eleştirileri ele almaya çalışacağız, daha sonra A. Plantinga’nın son dönem dini epistemolojisinin de yönünü belirleyen güvence (warrant) kavramını açıklayıp, bu kavramın bütün teist dinlere uygulanabilirliğini sorgulayacağız. (shrink)

Data preparation, feature engineering, model training, and performance evaluation are all part of the study methodology. To ensure reliable and broadly applicable models, we utilize optimization techniques like Grid Search and Genetic Algorithms to precisely adjust model parameters. Features including age, blood pressure, cholesterol levels, and lifestyle choices are employed as inputs for the machine learning models in the dataset, which consists of patient medical information. The predictive capacity of the model is evaluated using evaluation measures, such as accuracy, precision, (...) recall, F1-score, and the area under the ROC curve (AUC-ROC). Our findings show that improved machine learning models perform better than conventional methods, offering trustworthy forecasts that can help medical practitioners with early diagnosis and individualized treatment planning. (shrink)

Michael Hunter, The Boyle Papers: Understanding the Manuscripts of Robert Boyle. With contributions by Edward B. Davis, Harriet Knight, Charles Littleton and Lawrence M. Principe. Aldershot, England; Burlington, VT: Ashgate, 2007. Pp. xiii + 674. US$139.95/£70.00 HB. -/- The publication by Michael Hunter of this revised edition of the catalogue of the Boyle Papers contributes admirably to the renaissance in Boyle studies which has taken place over the past decade and a half. Robert Boyle (1627–91), arguably the most influential British (...) scientist of the late seventeenth century, was a pioneering experimenter, profound thinker, and figure-head of the new science in its early years of development. This volume brings together the materials necessary for understanding the Boyle archive, one of the most important archives from this period, which has been at the Royal Society since 1769. (shrink)

The paper examines the evolution of modernity concepts starting from the Renaissance to the present day, emphasizing the impact on architecture and urbanism. During the period of the Renaissance and the Enlightenment, people framed an evolutionary notion of history and the concept of the modern associated with the contemporary, the new, and the fleeting emerged. This period connected modernity with the idea of relativity of truth as opposed to the absolute truth of the Middle Ages. In the 18th and 19th (...) centuries, modernity clashed with tradition. This led to economic and political modernization. It also influenced artistic movements and cultural trends. The Industrial Revolution epitomized this period. It was driven by scientific and technological advancements. The paper discusses the objective and subjective perspectives of modernity, highlighting its dual nature in socioeconomic processes and personal experiences. Key thinkers like Habermas Weber and Baudelaire provide frameworks for understanding modernity's developments in science, art, and morality. The avant-garde movements influenced by Bauhaus, emphasized functionality. They also focused on rationality in architecture. However, critiques emerged, advocating the concept of unitary urbanism. This vision includes adaptable living spaces. It promotes an ever-changing urban environment, as exemplified by Constant's New Babylon. The Adorno's aesthetic theory criticized the industry's commodification of art and emphasizes art's utopian potential. Adorno's concept of mimesis and his critique of rationality and instrumental reason are explored reflecting the paradoxical nature of modernity. Finally, the paper contrasts the views of architects like Mies van der Rohe, Norberg-Schulz, and Eisenman. It concludes by reflecting on architecture's ongoing interaction with modernity. It emphasizes a balance between innovation tradition and the dynamic nature of human experience and social development. (shrink)

The dominant framework for addressing procreative ethics has revolved around the notion of harm, largely due to Derek Parfit’s famous non-identity problem. Focusing exclusively on the question of harm treats what procreators owe their offspring as akin to what they would owe strangers (if they owe them anything at all). Procreators, however, usually expect (and are expected) to parent the persons they create, so we cannot understand what procreators owe their offspring without also appealing to their role as prospective parents. (...) I argue that prospective parents can wrong their future children just by failing to act well in their role as parents, whether or not their offspring are ultimately harmed or benefitted by their creation. Their obligations as prospective parents bear on the motivations behind their reproductive choices, including the choice to select for some genetic trait in their offspring. Even when procreators’ motivations aren’t malicious, or purely selfish, they can still fail to recognize and act for the end of the parental role. Procreators can wrong their offspring by selecting for some genetic trait, then, when doing so would violate their obligations as prospective parents, or when their motivation for doing so is antithetical to the end of the parental role. (shrink)

Literature reviews have traditionally been a simple exercise in reporting the current relevant research, both to provide an overview of the current status of the field, and perhaps to draw attention to controversies. From the perspective of positivist research traditions, it was important to neutrally report all the relevant research, which was assumed to be foundational. In this article, written for the Applied Critical Realism special issue of Journal of Critical Realism, I use my own research to illustrate how a (...) literature review might look if it were non-foundational and guided by the principles of immanent critique. Immanent critique is central to Bhaskar’s philosophical methodology but has not been much applied in critical realist empirical research. Following a brief introduction to immanent critique, its history and relation to other ways of grounding knowledge, an excerpt from a literature review is used as backdrop for an extended discussion about various potential applications, and impl... (shrink)

I examine the epistemic import of collaborative research in science. I develop and defend a functional explanation for its growing importance. Collaborative research is becoming more popular in the natural sciences, and to a lesser degree in the social sciences, because contemporary research in these fields frequently requires access to abundant resources, for which there is great competition. Scientists involved in collaborative research have been very successful in accessing these resources, which has in turn enabled them to realize the epistemic (...) goals of science more effectively than other scientists, thus creating a research environment in which collaboration is now the norm. (shrink)

Back in Ancient India, Shankaracharya postulated a philosophy which is now known as Advaita. According to Advaita philosophy, the ‘jivãtma’ (individual soul) and ‘Brahmãtma’ (universal soul) are one and the same and these are the only ‘real’ things that exist. Everything else is an illusion. To challenge this almost unshakeable viewpoint, I bring to the fore a book authored by a Nobel Laureate. In 1935, Alexis Carrel’s revolutionary book entitled “Man the Unknown” was published. Though controversial in terms of its (...) content, it delineates the unexplored aspects of the human being – the understanding of mental processes and consciousness, which he claims humans have not mastered. Throughout the book, Carrel suggests that there is something that is unknown in the homo sapiens and hence he titles his work “Man the Unknown.” Based on this, I argue that both the esoteric East and the pragmatic West have not uncovered something “hidden” –the unknown factor/element. Substantial evidence exists for this contention in the scientific community. For example, questions such as among identical twins diagnosed with depression, why does one medication cure depression for one twin and have no effect on the other twin? Ceteris paribus, why does therapy work for one client but not for another client with the same disorder? These questions do not have clear, crystallized answers. Perhaps, if such a thing like an unknown element exists, it would pave the way for the postulation of the Grand Theory of the behavioural sciences. (shrink)

This chapter identifies and explores a series of challenges raised by the clinical concept of delusion for theories which conceive autonomy as an agency rather than a status concept. The first challenge is to address the autonomy-impairing nature of delusions consistently with their role as grounds for full legal and ethical excuse, on the one hand, and psychopathological significance as key symptoms of psychoses, on the other. The second challenge is to take into account the full logical range of delusions, (...) which may take the form of true or false factual beliefs, positive or negative evaluations, as well as the paradoxical delusion of mental illness. The third and final challenge is to make room for non-pathological or, autonomy-preserving delusions and to offer a credible way of distinguishing between these and pathological or, autonomy-impairing delusions. By setting out these challenges, we are able to, firstly, distinguish between two separate conceptions of objectivity that may be at work in existing accounts of delusions and, secondly, to put a spotlight on an elusive yet inescapable notion of agential success that underlies our thinking about autonomy as well as mental disorder. (shrink)

Here, I discuss how natural biological evolution might have selected human origin and the psychology of the better mind-brain. However, all humans are closely related; why do we make crimes, war, hate, and jealousy their primary reasons and overcoming methodologies? How can they gain their best happiness? What kind of philosophy apply to annalize this big question and convince humankind to evolve their mind? How we could achieve our optimum potential happiness by developing hidden intelligence to make the world a (...) happier place to live in. (shrink)

David Hull accounts for the success of science in terms of an invisible hand mechanism, arguing that it is difficult to reconcile scientists' self-interestedness or their desire for recognition with traditional philosophical explanations for the success of science. I argue that we have less reason to invoke an invisible hand mechanism to explain the success of science than Hull implies, and that many of the practices and institutions constitutive of science are intentionally designed by scientists with an eye to realizing (...) the very goals that Hull believes need to be explained by reference to an invisible hand mechanism. Thus, I reduce the scope of Hull's invisible hand explanation and supplement it by appealing to a hidden hand explanation. (shrink)

Many accounts of the morality of abortion assume that early fetuses must all have or lack moral status in virtue of developmental features that they share. Our actual attitudes toward early fetuses don’t reflect this all-or-nothing assumption: early fetuses can elicit feelings of joy, love, indifference, or distress. If we start with the assumption that our attitudes toward fetuses reflect a real difference in their moral status, then we need an account of fetal moral status that can explain that difference. (...) I argue that we can have or lack relational obligations to early fetuses in light of our own activities or choices, independent of the fetus’s own features or properties. Those relational obligations make the early fetus morally considerable to the persons who stand in a moral relation to it. Pregnant persons (and other participants in the procreative process) can come to have relational obligations to an early fetus just in virtue of their own decision to create a person, either by intentionally getting pregnant or by deciding to continue a pregnancy. That decision not only makes it appropriate for them to care about the fetus, but it also generates obligations to the fetus that they didn’t have before that decision. (shrink)

In this article I briefly explore Saint Augustine’s semiotics. I show how Augustine’s early, bipartite semiotics matured into a tripartite model that maps on to the Holy Trinity, and how this shift allows the Holy Spirit to take on a more distinct role in Augustine’s understanding of meaning. Further, this shift in Augustine’s thinking may help inform contemporary debates in the Augustine literature over how closely Augustine hews to Plotinus’ cosmology.

This paper explores how popular understandings of physical/mental supervenience can be employed to help support Robert Sokolowski’s enactivist theory of perception. The paper also investigates how the relationship between the world and our perceptions of it ties into the development and evolution of language and the terms we use to “say things about things.”.

Alvin Plantinga, analitik felsefe düşüncesi içerisinde yetişmiş ve bu gelenek içinde teistik din felsefesinin oluşumuna katkıda bulunmuş bir filozoftur. Ayrıca teizmin savunusu için yaptığı çalışmalarla, çeşitli üniversitelerden aldığı onur ödülleri ve 2017 yılında kazandığı Templeton Prize ödülüyle, haklı bir üne kavuşmuş bir şahsiyettir. Bu çalışmayı yapmamızdaki en önemli amaç, Plantinga’nın dini epistemoloji üzerine yaptığı çalışmaları analiz edip bu düşüncelerinin ardalanına dair bir tespitte bulunmaktır. Bu çalışmada yararlandığımız öncelikli kaynaklar, Plantinga’nın Nicholas Wolterstorff ile birlikte kaleme aldığı “Faith and Rationality” adlı eser (...) ile birlikte son dönem epistemik fikirlerinin çerçevesini belirleyen üç ciltlik “Warrant and Proper Function”, “Warrant: The Current Debate”, “Warranted: Christian Belief” isimli eserler olmuştur. Plantinga’nın ilk dönem epistemoloji çalışmalarının gayesini bir tür olumsuzlama diyebileceğimiz klasik temelciliğin ve evidentializmin eleştirisi oluştururken, ikinci döneminde bu eleştirilerden yola çıkarak Tanrı inancının haklı bir temelde ve güvenceye sahip olduğunu gösterme amacına yönelmiştir. Plantinga’nın teolojik fikirlerini oluşturan Kalvinci ekol, onun dini epistemolojisinin de özünü oluşturmaktadır. Plantinga’nın dini epistemolojisini iki boyutlu olarak değerlendirdiğimizde, içe dönük olarak Hristiyan inancıyla ilgilense de çalışmalarının dışsal yönünü daha genel olarak teizmin Tanrı’sı ve onun rasyonelliği oluşturmaktadır. Açıkçası Plantinga’nın epistemolojik külliyatı bir tür kavram zenginliğini de beraberinde getirmektedir. Çalışmamız içerisinde ele aldığımız kadarıyla uygun işlevsellik, tasarım planı, güvence (warrant) gibi kavramlar onun Tanrı inancının epistemik mahiyetini ortaya koymak için ne derece kararlı olduğunu göstermektedir. Netice itibariyle Tanrı inancının ve onun bilgisinin rasyonel olabileceğini ifade eden Plantinga, her ne kadar Hristiyan inancının belli bir koluna mensup olsa da diğer mezhepleri dışlamaz. Ayrıca Plantinga, birçok çalışmasında belirttiği üzere projesinin Yahudilik, İslam gibi diğer teistik dinlere yönelik olduğunu da belirtmektedir. (shrink)

The Aristotelian view that the moral virtues–the virtues of character informed by practical wisdom–are essential to an individual's happiness, and are thus in an individual's self-interest, has been little discussed outside of purely scholarly contexts. With a few exceptions, contemporary philosophers have tended to be suspicious of Aristotle's claims about human nature and the nature of rationality and happiness. But recent scholarship has offered an interpretation of the basic elements of Aristotle's views of human nature and happiness, and of reason (...) and virtue, that brings them more into line with common-sense thinking and with contemporary philosophical and empirical psychology. This makes it fruitful to reexamine the question of the role of virtue in self-interest. (shrink)

Cross-species comparisons are benefited by compatible datasets; conclusions related to phylogenetic comparisons, questions on convergent and divergent evolution, or homologs versus analogs can only be made when the behaviors being measured are comparable. A direct comparison of the social function of physical contact across two disparate taxa is possible only if data collection and analyses methodologies are analogous. We identify and discuss the parameters, assumptions and measurement schemes applicable to multiple taxa and species that facilitate cross-species comparisons. To illustrate our (...) proposed guidelines for evaluating the role played by tactile contact in social behavior across disparate taxa, this paper presents data on mother-offspring relationships in the two species studied by the authors: chimpanzees (Pan troglodytes schweinfurthii) and dolphins (bottlenose and spotted, Tursiops truncatus and Stenella frontalis, respectively). Cross-species comparative studies allow for a more comprehensive assessment of the similarities and differences with respect to how animals traverse the relationships that form their social groups and societies. (shrink)

Two of the staunchest critics of astrology presented their case in an article published in this journal that has since become a standard reference. The authors argue that the astrological experience is more likely to work by 'hidden persuaders' than by either objective or psychic criteria, yet their argument provides no evidence of this. The authors demand careful testing yet their own examples and claims against astrology are not careful. The metaanalysis claim mixes studies with widely disparate data types. The (...) parental tampering argument against Michel Gauquelin's planetary eminence findings lacks supportive evidence. The 'definitive' time twins test fails to define the criteria of resemblance. The test of predicting psychological test profiles does not discriminate between permanent personality dimensions and psychological states as astrology requires. The blind chart matching studies evaluated skills on the wrong parties where they would not be expected by either astrology or psychology. The authors fail to mention the most interesting and promising peer-reviewed astrological research studies that were available to them. Improved discourse with astrological subject matter experts is recommended. (shrink)

Many of our most important goals require months or even years of effort to achieve, and some never get achieved at all. As social psychologists have lately emphasized, success in pursuing such goals requires the capacity for perseverance, or "grit." Philosophers have had little to say about grit, however, insofar as it differs from more familiar notions of willpower or continence. This leaves us ill-equipped to assess the social and moral implications of promoting grit. We propose that grit has an (...) important epistemic component, in that failures of perseverance are often caused by a significant loss of confidence that one will succeed if one continues to try. Correspondingly, successful exercises of grit often involve a kind of epistemic resilience in the face of failure, injury, rejection, and other setbacks that constitute genuine evidence that success is not forthcoming. Given this, we discuss whether and to what extent displays of grit can be epistemically as well as practically rational. We conclude that they can be (although many are not), and that the rationality of grit will depend partly on features of the context the agent normally finds herself in. In particular, grit-friendly norms of deliberation might be irrational to use in contexts of severe material scarcity or oppression. (shrink)

“Doğal din” terimi, bazen doğanın kendisinin ilahi olduğu bir panteistik doktrine atıfta bulunur. “Doğal teoloji” terimi ise aksine, başlangıçta gözlemlenen doğal gerçekler temelinde (ve bazen) Tanrı’nın varlığını savunmaya yönelik projeye atıfta bulunur. Bununla birlikte çağdaş felsefede, hem “doğal din” hem de “doğal teoloji” genel olarak, dinî veya teolojik konuları araştırmak için insana, “doğal” olan bilişsel yetilerini – akıl, algı, içgözlem- kullanma projesini ifade eder. Doğal din veya teoloji, mevcut anlayış üzerine, doğayla ilgili ampirik araştırmalarla sınırlı olmamakla birlikte ayrıca panteistik bir (...) sonuçla da bağlantılı değildir. Bununla birlikte o, özel doğal olmayan yetilere (ESP, telepati, mistik deneyim) veya doğaüstü bilgi kaynaklarına (kutsal metinler, vahiy teolojisi, inanç otoriteleri, doğrudan doğaüstü iletişim) hitap etmekten kaçınır. Genel olarak, doğal din veya teoloji (bundan böyle “doğal teoloji” olarak anılacaktır), diğer felsefi ve bilimsel girişimlerle aynı rasyonel inceleme standartlarına uymayı amaçlamaktadır ve aynı değerlendirme ve eleştiri yöntemlerine tabidir. (shrink)

Though many agree that we need to account for the role that social factors play in inquiry, developing a viable social epistemology has proved to be difficult. According to Longino, it is the processes that make inquiry possible that are aptly described as "social," for they require a number of people to sustain them. These processes, she claims, not only facilitate inquiry, but also ensure that the results of inquiry are more than mere subjective opinions, and thus deserve to be (...) called "knowledge." In this paper, I (a) explain Longino's epistemology, and (b) defend it against charges that have recently been raised by Kitcher, Schmitt, and Solomon. Longino rightly recognizes that not all social factors have the same (adverse) affect on inquiry. She also recommends that we distinguish knowledge from mere opinion by reference to a social standard. (shrink)

Usually, modular construction involves the off-site manufacturing of standard building components in a factory before the components are assembled on the construction site. It is common to use terms like "prefabrication," "off-site construction," and "modular construction" interchangeably. The construction of modular constructions nowadays is flourishing all over the globe. The roots of the Albanian prefabricated constructions are extended for the first time around the 1970s. This paper will indeed analyze some recently built modular construction in Albania, considering and comparing it (...) with international case studies. The demand for new construction in Albania is rising rapidly. Currently, the most common structures are cast-in-place beam-column designs, driven by both traditional mindsets and industrial capabilities. However, with Albania's economic growth, there is an increasing need for affordable, quickly built, and technologically advanced buildings. Modular construction, which assembles prefabricated modules on-site, offers a solution. This method aligns with bioclimatic design principles, reducing environmental impact and optimizing resources, marking a shift toward sustainability in the construction industry. The purpose of this article is to explore the potential integration of “modular construction techniques” with “bioclimatic design concepts” to create buildings that are environmentally friendly, energy-efficient, and multipurpose by function. This study explores the use of modular construction techniques in conjunction with bioclimatic techniques to increase “building sustainability”. Combining these tactics encourages energy efficiency and a reduced environmental effect, making people far more resilient and weather-adaptable. The synergy between the two of them is necessary. (shrink)

Social commentary is the act of using rhetorical means to provide commentary on social, cultural, political, or economic issues in a society. This is often done with the idea of implementing or promoting change by informing the general populace about a given problem and appealing to people's sense of justice. Social commentary can be practiced through all forms of communication, from printed form, to conversations to computerized communication.

Public reason liberals expect individuals to have justificatory reasons for their views of certain political issues. This paper considers how groups can, and whether they should, give collective public reasons for their political decisions. A problem is that aggregating individuals’ consistent judgments on reasons and a decision can produce inconsistent collective judgments. The group will then fail to give a reason for its decision. The paper considers various solutions to this problem and defends a deliberative procedure by showing how it (...) incentivizes information sharing and leads to outcomes most acceptable to the group members. (shrink)

There is no doubt that custard apple diseases are among the important reasons that destroy the Custard Apple plant and its agricultural crops. This leads to obvious damage to these plants and they become inedible. Discovering these diseases is a good step to provide the appropriate and correct treatment. Determining the treatment with high accuracy depends on the method used to correctly diagnose the disease, expert systems can greatly help in avoiding damage to these plants. The expert system correctly diagnoses (...) Custard Apple disease to make it easier for farmers to find the right treatment based on the appropriate diagnosis. Objectives: A specialized syllable language system was established for the diagnosis of Custard Apple plant disease. (shrink)